HCID 11708770, 화합물 → 1-(4-hydroxyphenyl)pyrrolidin-2-one

HRID 1768130노트

반응식

HRID 1768130 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[CH:11][CH:10]=1)C1C=CC=CC=1.ClCCl.CO>C1COCC1.C(O)(=O)C.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[CH:11][CH:10]=1

참가 물질

6

반응물 2

HCID 11708770HCID 11708770, 화합물HCID 21226129Dichloromethane methanol

생성물 1

HCID 7855861-(4-hydroxyphenyl)pyrrolidin-2-one수율 66.4%

시약·촉매·용매 3

HCID 176Acetic Acid촉매HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

6.2 g (23.2 mmol) 1-(4-benzyloxy-phenyl)-pyrrolidin-2-one is dissolved in 200 ml THF. 3 drops of acetic acid are added and the solution is hydrogenated for 5 hours at RT and normal pressure in presence of 0.62 g palladium 10% on charcoal. Filtration and concentration gives a semisolid material. Chromatography (silica gel, dichloromethane/methanol 95:5) yields 2.73 g (66%) of a brownish solid. MS: m/e=175.9 (M−H).

후처리

  1. filtrationFiltration and concentration
  2. customgives a semisolid material

출처 및 근거

ORD 기록
ord-62365c17024d4fe0a584495a335ed946
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235581B2

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