Water → HCID 10450037, 화합물

HRID 1768133노트

반응식

HRID 1768133 반응식
C([O:3][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=3)=[CH:13][CH:12]=2)[C:7]1=[O:26])=O)C.[CH3:27][NH2:28].O>CN(C)C=O.C(O)C>[CH3:27][NH:28][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=3)=[CH:13][CH:12]=2)[C:7]1=[O:26])=[O:3]

참가 물질

6

반응물 3

HCID 962WaterHCID 6329MethylamineHCID 69491010HCID 69491010, 화합물

생성물 1

HCID 10450037HCID 10450037, 화합물수율 14%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6228Dimethylformamide용매

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온도
120 °C

실험 절차

300 mg (0.84 mmol) 1-[4-(3-Fluoro-benzyloxy)-phenyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester is dissolved in 2 ml N,N-dimethylformamide. 0.17 ml (4.2 mmol) of a 33% solution of methylamine in ethanol is added. The reaction vessel is tightly stoppered and heated to 120° C. for 24 hours. Addition of water precipitates the crude material. Chromatography (silica gel, dichloromethane/methanol) yields 41 mg (14%) of a yellowish solid. MS: m/e=343.2 (M+H)+.

후처리

  1. customprecipitates the crude material

출처 및 근거

ORD 기록
ord-b67f4566ef0b45ff89ef517b7833c3a7
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235581B2

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