Trifluoroacetic acid → Trans-[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetic acid

HRID 1768243노트

반응식

HRID 1768243 반응식
FC(F)(F)C(O)=O.C([CH:12]([C@H:16]1[CH2:22][CH2:21][C@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:19][N:18]([CH2:29][CH2:30][O:31][CH3:32])[C:17]1=[O:33])[C:13]([O-:15])=[O:14])(C)(C)C>ClCCl>[CH3:32][O:31][CH2:30][CH2:29][N:18]1[CH2:19][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:22][C@H:16]([CH2:12][C:13]([OH:15])=[O:14])[C:17]1=[O:33]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86595045(trans)-Tert-butyl[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetate

생성물 1

HCID 66939309Trans-[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1 mL) was added to a solution (trans)-tert-butyl[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetate (170 mg, 0.47 mmol) in dichloromethane (3 mL). After 2 h, the solution was concentrated. MS 306 (M+1).

후처리

  1. concentrationthe solution was concentrated

출처 및 근거

ORD 기록
ord-de3d95b9c2184a4c80566340e0d37d30
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235545B2

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