1-(3-Methyl-2-pyridinyl)piperazine → 2-{[4-(3-Methyl-2-pyridinyl)-1-piperazinyl]methyl}furo[3,2-b]pyridine

HRID 1768364

반응식

HRID 1768364 반응식
[CH3:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C(O[BH-](O[C:24](=[O:26])[CH3:25])OC(=O)C)(=O)C.[Na+]>>[CH3:1][C:2]1[C:3]([N:8]2[CH2:9][CH2:10][N:11]([CH2:7][C:6]3[O:26][C:24]4[C:25](=[N:4][CH:3]=[CH:2][CH:1]=4)[CH:5]=3)[CH2:12][CH2:13]2)=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 27600571-(3-Methyl-2-pyridinyl)piperazineHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 98614252-{[4-(3-Methyl-2-pyridinyl)-1-piperazinyl]methyl}furo[3,2-b]pyridine

실험 절차

The product from Example 35B, 1-(3-methyl-2-pyridinyl)piperazine, and sodium triacetoxyborohydride were processed as described in Example 35C to provide the title compound. 1H NMR (CDCl3, 300 MHz) δ 2.68 (m, 4H), 3.29 (s, 3H), 3.58 (m, 4H), 3.79 (s, 2H), 6.41 (d, J=8.48 Hz, 1H), 6.49 (d, J=7.12 Hz, 1H), 6.85 (s, 1H), 7.18 (dd, J=4.75, 8.14 Hz, 1H) 7.36 (dd, J=7.12, 8.14 Hz, 1H), 7.73 (dd, J=1.02, 8.14 Hz, 1H), 8.51 (dd, J=1.36, 4.75 Hz, 1H); MS (DCI/NH3) m/z 309.2 (M+H)+.

출처 및 근거

ORD 기록
ord-d2e9a13c5b664b599d1f367865c70d87
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235661B2

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