Hexane → 2-(chloromethyl)-1H-thieno[3,4-d]imidazole
반응식
[S:1]1[CH:5]=[C:4]([NH2:6])[C:3]([NH2:7])=[CH:2]1.[Cl:8][CH2:9][C:10](OCC)(OCC)OCC.CCCCCC>C(COC)OC>[Cl:8][CH2:9][C:10]1[NH:7][C:3]2=[CH:2][S:1][CH:5]=[C:4]2[N:6]=1참가 물질
5
반응 조건
- 온도
- 95 °C
실험 절차
3,4-Thiophenediamine (0.5 g, Toronto Research Chemicals, Chemical Abstracts # 90069-81-1) and 2-chloro-1,1,1-triethoxyethane (0.9 g) were combined in dimethoxyethane (7 mL) in a sealed tube and heated at 95° C. for one hour. After allowing to cool to room temperature and stirring for 24 hours, the mixture was treated with hexane (10 mL) and filtered. The filter cake was dried under reduced pressure to provide the title compound. MS (DCI/NH3) m/z 173 (M+H)+.
후처리
- temperatureto cool to room temperature
- filtrationfiltered
- customThe filter cake was dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-f00ae53982f64b8bb9e38a03c8ee3a72
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235661B2
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