6-Cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene → 6-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

HRID 1768638노트

반응식

HRID 1768638 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](O)([C:13]1[S:17][N:16]=[CH:15][CH:14]=1)[CH2:8][CH2:7][CH2:6]2)#[N:2]>C(O)(=O)C>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([C:13]1[S:17][N:16]=[CH:15][CH:14]=1)[CH2:8][CH2:7][CH2:6]2)#[N:2]

참가 물질

3

반응물 1

HCID 189490166-Cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

생성물 1

HCID 189490196-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Analogously to Example 4, 6-cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene (Example 15) in glacial acetic acid is convened into the title compound using tin(II) chloride and 36.5% hydrochloric acid.

출처 및 근거

ORD 기록
ord-3eb42e04ac354378978dfb8b47ed658e
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05378721

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