3-nitro-5,6,7,8-tetrahydroquinoline → 5,6,7,8-tetrahydroquinolin-3-amine

HRID 1768754노트

반응식

HRID 1768754 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=1

참가 물질

4

반응물 1

HCID 110303733-nitro-5,6,7,8-tetrahydroquinoline

생성물 1

HCID 106543695,6,7,8-tetrahydroquinolin-3-amine수율 97.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A suspension of 15.8 g of 3-nitro-5,6,7,8-tetrahydroquinoline [synthesized according to the method as described in Bull. Chem. Soc. Jpn. Vol. 63 (1990), 2820] and 1.6 g of 5% palladium carbon in 300 ml of methanol is hydrogenerated at ordinary temperature under atmospheric pressure. The catalyst is filtered off, and the filtrate is concentrated in vacuo to remove the solvent. The resultant crude product is recrystallized from methylene chloride-isopropyl ether to give 12.76 g of the titled compound 1. Yield: 97%

후처리

  1. customsynthesized
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo
  4. customto remove the solvent
  5. customThe resultant crude product is recrystallized from methylene chloride-isopropyl ether

출처 및 근거

ORD 기록
ord-c29840ef666e4471a41ec3482ef0cff0
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05378848

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