Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Piperazine, 1-(1-adamantyl)- | HCID 35373 | — |
| 반응물 | 4,5-Dichloro-3-hydroxypyridazine | HCID 73247 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine | HCID 18946304 | 73.7% |
반응 단계
A mixture of 1-(1-adamantyl)piperazine (2.2 g, 10 mmol), triethylamine (1.36 ml, 10 mmol) and 4,5-dichloro-3-oxo-2,3-dihydropyridazine (1.65 g, 10 mmol) in ethanol (25 ml) was heated under reflux for 5 hours. After cooling the precipitated solids were collected, washed with ethanol and dried to afford 2.57 g of the title compound, yield: 73.6%, mp. 292°-294° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05380724 |
| 출처 데이터셋 | uspto-grants-1995_01 |
| ORD ID | ord-983c00e751b44387b3912056b5a06470 |
| 출처 메모 | uspto-grants-1995_01 |