Water → 2-chloro-N-[4-(cyanomethyl)phenyl]acetamide

HRID 1768956노트

반응식

HRID 1768956 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1.O>CC(N(C)C)=O>[Cl:1][CH2:2][C:3]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1)=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 770004-Aminophenylacetonitrile

생성물 1

HCID 49623062-chloro-N-[4-(cyanomethyl)phenyl]acetamide수율 87.8%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

2-Chloroacetyl chloride (3.3 ml, 5.0 g, 44 mmol) was added dropwise at 10°-15° C. to a solution of 4-aminobenzylcyanide (5.3 g, 40 mmol) in dimethyl acetamide (20 ml) and the mixture was stirred at room temperature for one hour. After pouring into water the precipitate was collected, washed with water and dried over P2O5 under reduced pressure to give the title compound (7.33 g) as nearly colorless crystals, yield: 87.8%, mp 124°-125° C.

후처리

  1. customwas collected
  2. washwashed with water
  3. dry with materialdried over P2O5 under reduced pressure

출처 및 근거

ORD 기록
ord-78165c549a5d413e814d61de0f271d79
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05380724

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