Trifluoroacetic acid → HCID 15228076, 화합물

HRID 1769031노트

반응식

HRID 1769031 반응식
[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]1)=[O:16].FC(F)(F)C(O)=O.C(=O)([O-])O.[Na+]>>[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1)=[O:16]

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 540144471-[[(2-Ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl)methanone

생성물 1

HCID 15228076HCID 15228076, 화합물

실험 절차

Mix 1-[[(2-ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl]methanone (10.07 g, 26.67 mmol) and trifluoroacetic acid (75 mL). Stir at room temperature until the reaction is complete. Pour onto water and carefully neutralize with solid sodium hydrogen carbonate. Extract into ethyl acetate (2×), wash with brine and dry (MgSO4). Evaporate the solvent in vacuo and purify by chromatography to give the title compound.

후처리

  1. additionPour onto water
  2. extractionExtract into ethyl acetate (2×)
  3. washwash with brine
  4. dry with materialdry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. custompurify by chromatography

출처 및 근거

ORD 기록
ord-c2a19692b3094a1c9b0b889db26201ea
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05380731

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