Dimethylformamide → HCID 57294109, 화합물

HRID 1769032노트

반응식

HRID 1769032 반응식
[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16].[C:23]([CH2:27][O:28][CH2:29][CH2:30]Br)([O:25][CH3:26])=[O:24].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:18][CH2:19][N:20]([CH2:30][CH2:29][O:28][CH2:27][C:23]([O:25][CH3:26])=[O:24])[CH2:21][CH2:22]1)=[O:16]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 15228076HCID 15228076, 화합물HCID 18946503Methyl (2-bromoethoxy)acetate

생성물 1

HCID 57294109HCID 57294109, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

Mix 1-[[(2-ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(4-piperidinyl)]methanone (3.89 g, 12.91 mmol), carbomethoxy methoxy ethylbromide (3.01 g, 15.3 mmol), potassium carbonate (5.29 g, 38.25 mmol) and dimethylformamide (100 mL). Stir and heat and at 90° C. overnight. Allow to cool to room temperature, dilute with water and extract with ethyl acetate (2×). Wash the combined organic phases with water (3×), then brine and dry (MgSO4). Evaporate the solvent in vacuo to give and purify by chromatography to give the title compound.

후처리

  1. temperatureto cool to room temperature
  2. extractionextract with ethyl acetate (2×)
  3. washWash the combined organic phases with water (3×)
  4. dry with materialbrine and dry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. customto give
  7. custompurify by chromatography

출처 및 근거

ORD 기록
ord-db487e8cddab40ceaad5bdbe49b36991
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05380731

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