4-Methyl-3-nitrobenzotrifluoride → 2-Methyl-5-(trifluoromethyl)aniline

HRID 1769297

반응식

HRID 1769297 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-])=O>C(O)C.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[NH2:12]

참가 물질

4

반응물 1

HCID 14728854-Methyl-3-nitrobenzotrifluoride

생성물 1

HCID 27359332-Methyl-5-(trifluoromethyl)aniline수율 79.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-Methyl-5-trifluoromethylnitrobenzene (14.8 g) was dissolved in ethanol (100 ml) and hydrogenated at ambient temperature and pressure in the presence of palladium on charcoal (10%; 0.5 g). The solution was filtered and evaporated to dryness to give 2-methyl-5-trifluoromethylaniline (10.1 g) as a pale yellow oil.

후처리

  1. filtrationThe solution was filtered
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-a0521ef7ef064ea5981d79c5dc25bc44
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05380865

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