Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 2-(4-Methylbutyloxy)acetaldehyde diethylacetal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| 반응물 | (+)-2-Pentanol | HCID 2724896 | — |
| 생성물 | 2-(4-Methylbutyloxy)acetaldehyde diethylacetal | HCID 19930625 | — |
반응 단계
35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60 % sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution was concentrated and water and ether were added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05380915 |
| 출처 데이터셋 | uspto-grants-1995_01 |
| ORD ID | ord-3557c6b09319466facd659160f7875ef |
| 출처 메모 | uspto-grants-1995_01 |