Ethanol → 1-(Benzothiophen-2-yl)piperazine
반응식
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15]N[CH2:13][CH2:12]1.[CH2:17](O)C>>[S:3]1[C:2]([N:6]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:17][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]1=2참가 물질
4
실험 절차
2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.
후처리
- customThe mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate
- customThe organic phase is separated
- dry with materialdried with sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-3f77189919ef41888313d7a00664c0d6
- 출처 데이터셋
- uspto-grants-1995_01
- 특허 번호
- US05380840
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