Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Carbethoxyphthalimide → N-(1-benzylpyrrolidin-3-yl)phthalimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Carbethoxyphthalimide | HCID 31187 | — |
| 반응물 | 1-Benzyl-3-aminopyrrolidine | HCID 2756613 | — |
| 용매 | Methyl Chloride | HCID 6327 | — |
| 생성물 | N-(1-benzylpyrrolidin-3-yl)phthalimide | HCID 6711061 | 73.3% |
반응 단계
10.0 g of 3-amino-1-benzylpyrrolidine was dissolved into 10 ml of chloromethane, to which 12.4 g of N-ethoxycarbonylphthalimide was added and stirred at a room temperature for 10 hours. The solvent was distilled off, diethyl ether was added and insoluble matters were filtered out. The filtrate was concentrated and purified on silica gel column chromatography, to obtain 12.70 g of the above-captioned compound (yield: 73%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05382595 |
| 출처 데이터셋 | uspto-grants-1995_01 |
| ORD ID | ord-f61d9c4ab7e24c5f8a1c833d3e764a91 |
| 출처 메모 | uspto-grants-1995_01 |