Water → 1,1-Dimethylethyl 2-chloro-3-methoxymethyloxirane-carboxylate

HRID 1770191

반응식

HRID 1770191 반응식
[CH3:1][O:2][CH2:3][CH:4]=[O:5].Cl[CH:7]([Cl:15])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].CCOCC.O>O1CCCC1>[Cl:15][C:7]1([C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9])[CH:4]([CH2:3][O:2][CH3:1])[O:5]1

참가 물질

6

반응물 4

HCID 962WaterHCID 3283Diethyl EtherHCID 91563MethoxyacetaldehydeHCID 30164831,1-Dimethylethyl dichloroacetate

생성물 1

HCID 214784451,1-Dimethylethyl 2-chloro-3-methoxymethyloxirane-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
-20 °C

실험 절차

A mixture of 2.106 g of methoxyacetaldehyde, 3.8 ml of terbutyl dichloroacetate and 25 ml of tetrahydrofuran was cooled to -20° C. and over 15 minutes, 29 ml of potassium tertbutylate in tetrahydrofuran (0.9M) were introduced. The mixture stood for 20 minutes and 25 ml of ether and 25 ml of water were added. The mixture was extracted with ether and the organic phase was washed with water saturated with sodium chloride, then dried and concentrated to dryness under reduced pressure. The residue was chromatographed over silica and eluted with methylene chloride to obtain 1.44 g of 1,1-dimethylethyl 2-chloro-3-methoxymethyloxirane-carboxylate.

후처리

  1. extractionThe mixture was extracted with ether
  2. washthe organic phase was washed with water saturated with sodium chloride
  3. customdried
  4. concentrationconcentrated to dryness under reduced pressure
  5. customThe residue was chromatographed over silica
  6. washeluted with methylene chloride

출처 및 근거

ORD 기록
ord-c4cd59bbbd9844b58b9c6eb8889d715c
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05385897

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