Water → Nitrofen

HRID 17702

반응식

HRID 17702 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[OH:25].O>CN(C=O)C>[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[O:25][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 84492,4-DichlorophenolHCID 9590p-FluoronitrobenzeneHCID 11430Potassium Carbonate

생성물 1

HCID 15787Nitrofen

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 2,4-dichlorophenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H2O (100 ml), extracted with EtOAc (2×50 mL), washed with H2O (2×50 ml) and brine (50 ml), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(2,4-dichloro-phenoxy)-1-nitrobenzene. The crude product was used for further transformation.

후처리

  1. temperatureAfter cooling to rt
  2. extractionextracted with EtOAc (2×50 mL)
  3. washwashed with H2O (2×50 ml) and brine (50 ml)
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuuo

출처 및 근거

ORD 기록
ord-2c6d60100ffe4f218f9f5c033c50600a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737285B2

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