Aniline → HCID 15022346, 화합물

HRID 1770320노트

반응식

HRID 1770320 반응식
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

참가 물질

5

반응물 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

생성물 1

HCID 15022346HCID 15022346, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 312751,4-Dioxane용매

실험 절차

4-Chlorothiophene-3-carbonyl chloride (13.5 g, 0.075 mol) are dissolved in 30 ml of dioxane and the solution is added dropwise at room temperature to a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). Stirring is carried out for 12 hours at room temperature, after which the mixture is evaporated to dryness and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and evaporated to dryness. Yield: 16.7 g, 94%; mp. 119° to 121° C.

후처리

  1. customafter which the mixture is evaporated to dryness
  2. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  3. customdried
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d6e97c5bb61e42c1a2ac2eb24abb4254
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05386036

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