tert-Butyldimethylsilyl chloride → HCID 59524419, 화합물

반응식

Cl.[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1.[C:17]([Si:21](Cl)([CH3:23])[CH3:22])([CH3:20])([CH3:19])[CH3:18]>>[Si:21]([O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:23])[CH3:22]

참가 물질

반응물 2

HCID 28928tert-Butyldimethylsilyl chloride

HCID 66975332Methyl (R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride

생성물 1

HCID 59524419HCID 59524419, 화합물수율 79%

실험 절차

Prepared as in Example 1c-JF from (R)-methyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (Example 13-2c) and tert-butylchlorodimethylsilane. Yield 79%, yellow oil (1.15 g, 79%). MS 322 (MH+).

출처 및 근거

ORD 기록: ord-80b5b3d8bed24e778d35ba0c5d4bd61a
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09247759B2

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