Benzyl Alcohol → Benzyl 2-bromo-2,2-difluoroacetate

HRID 1771028노트

반응식

HRID 1771028 반응식
[Br:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8](O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1CCCCC1>[Br:1][C:2]([F:7])([F:6])[C:3]([O:5][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:4]

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 521998p-Toluenesulfonic acid monohydrateHCID 27732822-Bromo-2,2-difluoroacetic acid

생성물 1

HCID 10378165Benzyl 2-bromo-2,2-difluoroacetate

시약·촉매·용매 1

HCID 8078Cyclohexane용매

실험 절차

This compound was prepared according to Example 2a from bromodifluoroacetic acid (9.82 g; 68.7 mmol), benzyl alcohol (7.0 g; 65 mmol), and p-toluenesulphonic acid monohydrate (50 mg) in cyclohexane (120 mL). The crude product obtained after evaporation was used as is without any further workup in 3b.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-73f25d56bc8441348449fcc0b66adb7e
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249086B2

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