Methanol → Methyl (R)-3-[(benzyloxycarbonyl)amino]-4-hydroxybutanoate

HRID 1771160

반응식

HRID 1771160 반응식
[O:1]=[C:2]1[O:6][CH2:5][C@H:4]([NH:7][C:8](=[O:17])[O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:3]1.C(N(CC)CC)C.[CH3:25][OH:26]>>[CH2:10]([O:9][C:8]([NH:7][C@@H:4]([CH2:25][OH:26])[CH2:3][C:2]([O:6][CH3:5])=[O:1])=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 8471TriethylamineHCID 697924(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate2회

생성물 1

HCID 59108917Methyl (R)-3-[(benzyloxycarbonyl)amino]-4-hydroxybutanoate

실험 절차

(R)-Benzyl 5-oxotetrahydrofuran-3-ylcarbamate (INTERMEDIATE 3, 27.0 g, 114.78 mmol) was dissolved in methanol (75 ml) and triethylamine (75 ml) was added at room temperature. The resulting mixture was allowed to stir overnight at this temperature. The mixture was concentrated in vacuo to provide the title product. This material was used to prepare INTERMEDIATE 5 without further purification.

후처리

  1. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-79bedf261bf8412f87aa039514b9c9ac
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09248140B2

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