4-Fluorophenylboronic acid → 6-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine

HRID 1771313노트

반응식

HRID 1771313 반응식
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:18][CH:17]=1

참가 물질

3

반응물 2

HCID 2856454-Fluorophenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

생성물 1

HCID 673636766-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine수율 46.5%

실험 절차

6-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine (99 mg, 46%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and 4-fluorophenylboronic acid (0.112 g, 0.80 mmol) according to the general procedure of Example 1.

출처 및 근거

ORD 기록
ord-4ed496f5542542f1b6b66d61edc587ee
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249130B2

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