2-Chlorophenylboronic acid → 6-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine

반응식

Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1B(O)O>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 27343222-Chlorophenylboronic acid

HCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

생성물 1

HCID 673627226-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine수율 45.5%

실험 절차

6-(2-Chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine (103 mg, 45%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and 2-chlorophenylboronic acid (0.125 g, 0.80 mmol) according to the general procedure of Example 1.

출처 및 근거

ORD 기록: ord-7f790bf2ff454b378f92f5c51081b835
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249130B2

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