Potassium Carbonate → 6-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine

HRID 1771355노트

반응식

Cl[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[K+].[K+].Cl.[F:22][C:23]1([F:29])[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[F:22][C:23]1([F:29])[CH2:28][CH2:27][N:26]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:25][CH2:24]1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 27583514,4-Difluoropiperidine hydrochloride

HCID 866761156-Chloro-5-phenyl-1,2,4-triazin-3-amine

생성물 1

HCID 673637236-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine수율 14%

실험 절차

6-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine (39 mg, 14%) was prepared from 6-chloro-5-phenyl-1,2,4-triazin-3-amine (0.20 g, 0.96 mmol), K2CO3 (0.23 g, 1.67 mmol) and 4,4-difluoropiperidine hydrochloride (0.22 g, 1.45 mmol) according to the general procedure of Example 2.

출처 및 근거

ORD 기록: ord-93d7b0478ddb4bb7998bae03551f0304
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249130B2

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