HCID 71766904, 화합물 → HCID 71766907, 화합물
반응식
Cl[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]1[NH:13][CH2:14][CH2:15][N:16]=1.[C:17]([Zn]C#N)#[N:18]>CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C.CN(C=O)C>[NH:13]1[CH2:14][CH2:15][N:16]=[C:12]1[CH:7]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:2]([C:17]#[N:18])[C:3]=2[CH2:4][CH2:5][O:6]1참가 물질
5
반응 조건
- 온도
- 160 °C
실험 절차
A mixture of 2-(5-chloroisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg), dicyanozinc (25 mg), bis(tri-t-butylphosphine)palladium(0) (3 mg) and DMF (2 ml) was stirred in microwave reactor at 160° C. for 30 minutes. The title compound was purified with separation methods F and G. (Yield 22 mg).
후처리
- customThe title compound was purified with separation methods F and G
출처 및 근거
- ORD 기록
- ord-cc1510cec0f14b289b154a84fc77cdcd
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249127B2
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