4-Carboxyphenylboronic Acid → HCID 57387163, 화합물

반응식

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([F:12])=[C:7]([OH:13])[CH:6]=[CH:5]2.B([C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=1)(O)O>>[F:12][C:8]1[C:7]([OH:13])=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2]([C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=1)=[CH:3]2

참가 물질

반응물 2

HCID 3121834-Carboxyphenylboronic Acid

HCID 112419406-Bromo-1-fluoronaphthalen-2-OL2회

생성물 1

HCID 57387163HCID 57387163, 화합물

실험 절차

Followed the coupling procedure described in Example 29 starting from 6-bromo-1-fluoronaphthalen-2-ol (Intermediate 13) and 4-boronobenzoic acid. 1H-NMR (DMSO-d6, 300 MHz, TMS): δ 13.04 (b, 1H), 10.23 (b, 1H), 8.29 (s, 1H), 7.91-8.01 (m, 7H), 7.74 (d, 1H). MS (ESI): m/z=281.26 [M−1]−.

출처 및 근거

ORD 기록: ord-8dd0a9f07fa64f6a863948c061d9cbad
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249132B2

반응 노트

불러오는 중…