4-(4,6-Dichloropyrimidin-2-yl)morpholine → 1-(4-(6-Chloro-2-morpholinopyrimidin-4-yl)phenyl)-3-ethylurea

HRID 1771546노트

반응식

HRID 1771546 반응식
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][C@@H:9]2C)[N:5]=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][CH2:25][CH3:26])=[O:23])=[CH:17][CH:16]=2)[CH:3]=1.ClC1C=C(Cl)N=C(N2CCOCC2)N=1>>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[N:5]=[C:4]([C:15]2[CH:16]=[CH:17][C:18]([NH:21][C:22]([NH:24][CH2:25][CH3:26])=[O:23])=[CH:19][CH:20]=2)[CH:3]=1

참가 물질

3

반응물 2

HCID 27720684-(4,6-Dichloropyrimidin-2-yl)morpholineHCID 86691150(S)-1-(4-(6-chloro-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

생성물 1

HCID 866911511-(4-(6-Chloro-2-morpholinopyrimidin-4-yl)phenyl)-3-ethylurea

실험 절차

Method as described for Intermediate 2 using 4-(4,6-dichloropyrimidin-2-yl)morpholine.

출처 및 근거

ORD 기록
ord-78be874bfe2f4afb901cf5dbd6f535c8
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249129B2

반응 노트

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