Nitric Acid → N-(2,6-dimethyl-3-nitrophenyl)acetamide

HRID 1771632

반응식

HRID 1771632 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:12])[CH3:11].[N+:13]([O-])([OH:15])=[O:14]>OS(O)(=O)=O.C(O)(=O)C>[CH3:8][C:4]1[C:5]([N+:13]([O-:15])=[O:14])=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10](=[O:12])[CH3:11]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 16616N-Acetyl-2,6-xylidine

생성물 1

HCID 223591N-(2,6-dimethyl-3-nitrophenyl)acetamide수율 94%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 1118Sulfuric Acid용매2회

실험 절차

N-(2,6-dimethylphenyl)acetamide (10 g, 60 mmol, 1.0 eq) was dissolved in a mixture of H2SO4 (40 mL) and acetic acid (20 mL) at 0° C. A mixture of HNO3 (10 mL) and H2SO4 (8 mL) was added dropwise with stirring. The reaction was allowed to warm to room temperature and stirred for a further 1 h. The reaction was quenched by pouring into ice water, and the solid that formed collected by filtration to give the title compound as a yellow solid (12 g, 94%).

후처리

  1. additionwas added dropwise
  2. stirringstirred for a further 1 h
  3. customThe reaction was quenched
  4. additionby pouring into ice water
  5. customthe solid that formed
  6. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-fe6f7a514b84428db5384ca2a0996faa
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249085B2

연결된 노트

불러오는 중…