Water → 5-Bromo-2-hydroxy-3-methylbenzoic acid

HRID 1771692노트

반응식

HRID 1771692 반응식
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>C(O)(=O)C>[Br:12][C:8]1[CH:9]=[C:10]([CH3:11])[C:2]([OH:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 67383-Methylsalicylic AcidHCID 24408Bromine

생성물 1

HCID 27643455-Bromo-2-hydroxy-3-methylbenzoic acid수율 90%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-hydroxy-3-methyl-benzoic acid (10 g, 66.7 mmol, 1.0 eq) in acetic acid (100 mL) was added bromine (10.66 g, 66.7 mmol, 1.0 eq) slowly over 5 min. The mixture was stirred at room temperature for 24 h, then water was added slowly and the mixture was stirred for a further 30 min. The precipitate was collected by filtration and was washed with water and dried to give the title compound as a white solid (13.7 g, 90%).

후처리

  1. stirringthe mixture was stirred for a further 30 min
  2. filtrationThe precipitate was collected by filtration
  3. washwas washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-b149146ff32147459cb49995c534d411
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249085B2

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