Ammonia → HCID 81430592, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[C:5](O)=[O:6].O=S(Cl)Cl.[NH3:19]>C1COCC1>[Br:1][C:2]1[CH:10]=[C:9]([CH:8]=[C:4]([C:5](=[O:6])[NH2:19])[CH:3]=1)[C:11]([O:13][CH3:14])=[O:12]참가 물질
5
실험 절차
To 3-bromo-5-methoxycarbonyl-benzoic acid (3 g, 11.6 mmol, 1 eq) was added SOCl2 (20 mL) and the reaction heated at reflux overnight. The excess SOCl2 was removed in vacuo and the residue obtained was dissolved in THF (15 mL) and added dropwise to a solution of NH3 (38% aqueous, 30 mL). The precipitate that formed was collected by filtration, washed with water and dried to give the title compound as a white solid (2.8 g, 94%).
후처리
- temperaturethe reaction heated
- temperatureat reflux overnight
- customThe excess SOCl2 was removed in vacuo
- customthe residue obtained
- customThe precipitate that formed
- filtrationwas collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-d8820c0f221b4cf49ec566a59d595dc0
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249085B2
반응 노트
불러오는 중…