HCID 68089188, 화합물 → HCID 86667806, 화합물
반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[N:4]=[C:3]1[CH2:15][OH:16]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[N:4]=[C:3]1[CH:15]=[O:16]참가 물질
4
실험 절차
To a solution of (3-methyl-3H-imidazo[4,5-h]quinolin-2-yl)methanol (560 mg, 2.62 mmol) in DCM (10 mL) was added manganese (IV) oxide (2.28 g, 26.2 mmol). The mixture was stirred at room temperature for 12 h. The solid was removed by filtration and the filtrate was concentrated. The crude product was purified by silica gel column chromatography (eluting with PE/EtOAc v/v 2:1) to give 3-methyl-3H-imidazo[4,5-h]quinoline-2-carbaldehyde as a yellow solid (370 mg, yield: 67.5%). ESI MS: m/z 212 [M+H]+.
후처리
- customThe solid was removed by filtration
- concentrationthe filtrate was concentrated
- customThe crude product was purified by silica gel column chromatography (
- washeluting with PE/EtOAc v/v 2:1)
출처 및 근거
- ORD 기록
- ord-d0b0bd73fd6041d8be3679470a9c179e
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249162B2
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