1,7-Naphthyridin-8-amine → HCID 86667814, 화합물

HRID 1772025

반응식

HRID 1772025 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[N:8][C:9]=2[NH2:11])[CH:4]=[CH:3][CH:2]=1.[C:12]1([CH3:25])[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]([CH3:19])[C:13]=1[S:20]([O:23][NH2:24])(=[O:22])=[O:21]>C(Cl)Cl>[NH:11]=[C:9]1[C:10]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH:6]=[CH:7][N:8]1[NH2:24].[CH3:19][C:14]1[CH:15]=[C:16]([CH3:18])[CH:17]=[C:12]([CH3:25])[C:13]=1[S:20]([O-:23])(=[O:22])=[O:21]

참가 물질

4

반응물 2

HCID 27370371,7-Naphthyridin-8-amineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

생성물 1

HCID 86667814HCID 86667814, 화합물수율 80.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a solution of 1,7-naphthyridin-8-amine (600 mg, 4.13 mmol) in DCM (5 mL) was added a solution of O-(mesitylsulfonyl)hydroxylamine (2.7 g, 12.4 mmol) in DCM (10 mL) at 0° C. The mixture was stirred at 0° C. for 2 h. The precipitate was filtered and collected to give 8-imino-1,7-naphthyridin-7(8H)-amine-2,4,6-trimethylbenzenesulfonate as a brown solid (1.2 g, yield 67%). ESI MS: m/z 161.1 [M+H]+.

후처리

  1. filtrationThe precipitate was filtered
  2. customcollected

출처 및 근거

ORD 기록
ord-1d46f4df65e6431c9f0ff6094791ee48
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249162B2

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