Acetonitrile → 4-Methyl-3-carbonyl valeronitrile
반응식
[C:1](OC)(=O)[CH:2]([CH3:4])C.[O-:8][CH2:9][CH3:10].[Na+].[C:12](#[N:14])[CH3:13]>CO>[CH3:1][CH:2]([CH3:4])[C:10](=[C:9]=[O:8])[CH2:13][C:12]#[N:14]참가 물질
5
실험 절차
To a 1 L of round bottom flask were added methyl isobutyrate (100 g, 0.98 mol), sodium ethoxide (66.63 g, 0.98 mol), acetonitrile (53.9 g, 0.98 mol) and 300 ml of methanol at room temperature. The resultant mixture was slowly warmed and refluxed. The reaction was kept for 6 hr. The reaction was stopped and cooled to room temperature. The solvent was rotary-evaporated. The product was distilled under reduced pressure (12 mmHg) to collect at 102-104° C. 56.2 g of the pure title compound.
후처리
- temperaturerefluxed
- customThe solvent was rotary-evaporated
- distillationThe product was distilled under reduced pressure (12 mmHg)
- customto collect at 102-104° C
출처 및 근거
- ORD 기록
- ord-e8b5ee671ec84da7bdcf9070e0f4e98a
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249172B2
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