Ethyl Acetate → 4-(4-Chloro-2-cyclohexylphenoxy)-1-nitrobenzene

HRID 17725

반응식

HRID 17725 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:19]=1.CCOC(C)=O>CN(C=O)C>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[C:20]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:19]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 9590p-FluoronitrobenzeneHCID 11430Potassium CarbonateHCID 831204-Chloro-2-cyclohexylphenol

생성물 1

HCID 669774044-(4-Chloro-2-cyclohexylphenoxy)-1-nitrobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (10 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-2-cyclohexylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (80 ml), washed with H2O (2×40 ml) and brine (60 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-chloro-2-cyclohexylphenoxy)-1-nitrobenzene. The crude product was used for further transformation.

후처리

  1. temperatureAfter cooling to rt
  2. washwashed with H2O (2×40 ml) and brine (60 mL)
  3. dry with materialdried over sodium sulfate
  4. customThe solvent was removed in vacuuo

출처 및 근거

ORD 기록
ord-31e3056647044bc28e7ac833a0dea674
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737285B2

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