Water → 5-Bromo-N-(tert-butyl)pyridine-2-sulfonamide

HRID 1772661노트

반응식

HRID 1772661 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8](Cl)(=[O:10])=[O:9])=[N:6][CH:7]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:16][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 445580975-Bromopyridine-2-sulfonyl chloride

생성물 1

HCID 711166495-Bromo-N-(tert-butyl)pyridine-2-sulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 5-bromopyridine-2-sulfonyl chloride (2.7 g, 10 mmol) in DCM (100 mL) was cooled to 0° C. and treated with tert-BuNH2 (5.5 mL, 52 mmol). The resulting mixture was stirred at rt for 48 h. Water (50 mL) was added and the DCM layer were separated, dried and concentrated to obtain compound 32a. 1H-NMR (400 MHz, CDCl3) δ (ppm): 8.75 (d, J=2.3 Hz, 1H), 8.03 (dd, J=8.2, 2.3 Hz, 1H), 7.90-7.94 (m, 1H), 5.02-5.07 (m, 1H), 1.23 (s, 9H).

후처리

  1. customthe DCM layer were separated
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ecd019b54a7644189cf319967949951e
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249163B2

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