3,3-Difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)indolin-2-one → Potassium 3,3-difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)-2-oxoindolin-1-ide

HRID 1772667노트

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HRID 1772667 반응식
[F:1][C:2]1([F:39])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]4[CH:17]=[C:18]([CH2:20][CH2:21][C:22]5[CH:31]=[CH:30][C:29]6[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=6)[N:23]=5)[N:19]=[C:15]4[C:14]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[N:13][CH:12]=3)[CH:9]=2)[NH:4][C:3]1=[O:38].O(C)[K:41]>CO>[F:39][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]4[CH:17]=[C:18]([CH2:20][CH2:21][C:22]5[CH:31]=[CH:30][C:29]6[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=6)[N:23]=5)[N:19]=[C:15]4[C:14]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)=[N:13][CH:12]=3)[CH:9]=2)[N-:4][C:3]1=[O:38].[K+:41]

참가 물질

4

반응물 2

HCID 863456813,3-Difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)indolin-2-oneHCID 178502595HCID 178502595, 화합물

생성물 1

HCID 123133231Potassium 3,3-difluoro-5-(8-morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl)-2-oxoindolin-1-ide

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

Compound 37c (65.3 mg, 0.124 mmol) was added to a MeOH solution of KOMe (8.69 mg, 0.124 mmol) at 0° C. The resulting mixture was stirred at 0° C. for 15 min, allowed to warm to rt, and stirred for another 30 min. The resulting mixture was concentrated and the resulting residue was dried under reduced pressure to obtain the title compound 59. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 8.25 (d, J=8.6 Hz, 1H), 7.92 (d, J=8.3 Hz, 2H), 7.71 (t, J=7.7 Hz, 1H), 7.45-7.59 (m, 4H), 7.40 (br. s., 1H), 7.26 (s, 1H), 6.84 (d, J=7.6 Hz, 1H), 4.06 (m, 4H), 3.68 (m, 4H) 3.27-3.35 (m, 2H), 3.19-3.27 (m, 2H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C29H24F2N6O2: 527.2 (M+H). Found 527.5.

후처리

  1. temperatureto warm to rt
  2. stirringstirred for another 30 min
  3. concentrationThe resulting mixture was concentrated
  4. customthe resulting residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-5b33b9fcad724849bc97260239410c45
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249163B2

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