Sodium Methoxide → HCID 86345769, 화합물

HRID 1772684노트

반응식

HRID 1772684 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:13]=[C:14](/[CH:16]=[CH:17]/[C:18]4[CH:27]=[C:26]([C:28]([OH:30])=[O:29])[C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1.C[O-].[Na+:33]>CO>[Na+:33].[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:13]=[C:14](/[CH:16]=[CH:17]/[C:18]4[CH:27]=[C:26]([C:28]([O-:30])=[O:29])[C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 86345770HCID 86345770, 화합물

생성물 1

HCID 86345769HCID 86345769, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a slurry of (E)-2-(2-(8-morpholinoimidazo[1,2-a]pyrazin-2-yl)vinyl)quinoline-4-carboxylic acid (32 mg, 0.08 mmol) in MeOH (0.6 mL), 1.5 M NaOMe in MeOH (0.16 mL, 0.08 mmol) was added. The resulting mixture was stirred for 10 min, concentrated, and dried under reduced pressure to obtain the title compound 8. 1H NMR (400 MHz, CD3OD) δ (ppm): 8.36 (d, J=8.6 Hz, 1H), 7.92-8.04 (m, 3H), 7.67-7.82 (m, 4H), 7.55 (t, J=7.6 Hz, 1H), 7.32 (d, J=4.4 Hz, 1H), 4.24-4.32 (m, 4H), 3.89 (t, 4H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C22H19N5O3: 402.2 (M+H). Found 402.4.

후처리

  1. concentrationconcentrated
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-877d75f1e3ee4477887d05926b818631
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249163B2

반응 노트

불러오는 중…