참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 3,5-Dibromo-2-chloropyrazine | HCID 53350358 | — |
| 생성물 | 6-Bromo-3-chloropyrazin-2-amine | HCID 56965723 | 66% |
반응 단계
Into a 250 mL sealed tube was placed compound 90d (50.0 g, 184 mmol) and NH4OH (150 mL). The resulting mixture was stirred overnight at 100° C. Upon cooling, a solid was collected by filtration and dried in an oven under reduced pressure to obtain the compound 90e as a grey solid (28.0 g, 66% yield), which was used in next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09249163B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_02 |
|---|
| ORD ID | ord-d5f3122d6ae94ffd963d262464e523f4 |
|---|
| 출처 메모 | uspto-grants-2016_02 |
|---|
