N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide → 2-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide

HRID 1772879노트

반응식

HRID 1772879 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-])=O)(=[O:12])=[O:11])=[CH:5][C:4]=1[CH3:22]>[Pd].C(O)C.CCOC(C)=O>[NH2:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[S:10]([NH:9][C:6]1[CH:7]=[N:8][C:3]([O:2][CH3:1])=[C:4]([CH3:22])[CH:5]=1)(=[O:11])=[O:12]

참가 물질

4

반응물 1

HCID 90022532N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide

생성물 1

HCID 900307172-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide수율 106.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

A mixture of N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide (2.69 g, 8.32 mmol) and 10% palladium on charcoal (1.35 g) in ethanol/EtOAc (1:1, 100 mL total reaction volume) was stirred at rt under an atmosphere of H2 for approximately 2.5 h. Filtration and concentration in vacuo yielded the crude title compound (2.60 g).

후처리

  1. filtrationFiltration and concentration in vacuo

출처 및 근거

ORD 기록
ord-886338baa49241c6a370f08fa640ef18
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249160B2

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