6-Bromo-3-methoxy-2-nitropyridine → 2-Amino-6-bromo-3-methoxypyridine

HRID 1772884노트

반응식

HRID 1772884 반응식
[Br:1][C:2]1[N:7]=[C:6]([N+:8]([O-])=O)[C:5]([O:11][CH3:12])=[CH:4][CH:3]=1>[Fe].CC(O)=O>[Br:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([O:11][CH3:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 226151626-Bromo-3-methoxy-2-nitropyridine

생성물 1

HCID 575629062-Amino-6-bromo-3-methoxypyridine수율 81.2%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

반응 조건

온도
90 °C

실험 절차

A mixture of 6-bromo-3-methoxy-2-nitropyridine (14.4 g, 61.8 mmol), AcOH (200 mL) and Fe powder (14.0 g, 0.25 mol) was stirred at 90° C. for 1.5 h. After cooling to rt and dilution with EtOAc the mixture was filtered through celite and the filtrate concentrated in vacuo. Purification by flash chromatography eluting with DCM yielded the title compound (10.2 g, 50.2 mmol) as a white solid.

후처리

  1. temperatureAfter cooling to rt
  2. filtrationdilution with EtOAc the mixture was filtered through celite
  3. concentrationthe filtrate concentrated in vacuo
  4. customPurification by flash chromatography
  5. washeluting with DCM

출처 및 근거

ORD 기록
ord-796c49612d6244109b8cd94804124d62
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249160B2

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