홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-Fluorobenzenesulphonyl chloride → 2-Fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide

HRID 1772895
노트
인쇄 미리보기

반응식

HRID 1772895 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH2:12][C:13]1[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=1>O1CCOCC1.CO>[NH3:12].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:12][C:13]1[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=1)(=[O:10])=[O:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 102200055-Amino-1-methyl-1,2-dihydropyridin-2-one

생성물 2

HCID 222AmmoniaHCID 472988402-Fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide수율 82.6%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 31275

실험 절차

2-Fluorobenzenesulfonyl chloride (0.46 mL, 3.5 mmol) was added to a solution of 5-amino-1-methyl-1,2-dihydropyridin-2-one (478 mg, 3.85 mmol) in 1,4-dioxane (10 mL) and stirred for 28 h at rt. After concentration in vacuo purification by column chromatography eluting with DCM:MeOH:7M NH3 in MeOH (90:5:5) yielded the title compound (448 mg, 1.59 mmol).

후처리

  1. concentrationAfter concentration
  2. customin vacuo purification by column chromatography
  3. washeluting with DCM

출처 및 근거

ORD 기록
ord-fab72010499b416091a1aafb64c5aa9b
출처 데이터셋
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09249160B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트
1,4-Dioxane
용매