Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-6-fluorobenzylamine → 2-[(2-Chloro-6-fluorobenzyl)amino]-N-(2-methoxypyrimidin-5-yl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-6-fluorobenzylamine | HCID 84833 | — |
| 반응물 | 2-Fluorobenzenesulphonyl chloride | HCID 137761 | — |
| 반응물 | 2-Methoxypyrimidin-5-amine | HCID 352904 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-[(2-Chloro-6-fluorobenzyl)amino]-N-(2-methoxypyrimidin-5-yl)benzenesulfonamide | HCID 90021903 | 9% |
반응 단계
The title compound (106 mg, impure, used without further purification) was prepared in two steps from 2-fluorobenzenesulfonyl chloride (0.46 mL, 3.5 mmol) and 5-amino-2-methoxypyrimidine (482 mg, 3.85 mmol) in 1,4-dioxane at 100° C.; followed by 2-chloro-6-fluorobenzyl amine (0.36 mL, 2.8 mmol) in MeCN (1.5 mL) at 180° C. in a Biotage Initiator microwave reactor using the methods of (IntB1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09249160B2 |
| 출처 데이터셋 | uspto-grants-2016_02 |
| ORD ID | ord-b2ab220cfe2c403abf927cfa50f04389 |
| 출처 메모 | uspto-grants-2016_02 |