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Ammonia → 2-(2,6-Dimethoxypyridin-4-yl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

HRID 1772933
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HRID 1772933 반응식
Cl[C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[C:18]([NH2:20])[CH:17]=[C:16]([O:21][CH3:22])[N:15]=1.N.[C:24](N1C=CN=C1)([N:26]1C=CN=C1)=[O:25]>N1C=CC=CC=1.ClCCCl>[CH3:22][O:21][C:16]1[CH:17]=[C:18]([N:20]2[C:24](=[O:25])[NH:26][C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[S:8]2(=[O:10])=[O:9])[CH:19]=[C:14]([O:13][CH3:12])[N:15]=1
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참가 물질

7

반응물 4

HCID 222AmmoniaHCID 682631,1'-CarbonyldiimidazoleHCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 222201912,6-Dimethoxypyridin-4-amine

생성물 1

HCID 900547912-(2,6-Dimethoxypyridin-4-yl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide수율 20.2%

시약·촉매·용매 2

HCID 11
1,2-Dichloroethane
용매
HCID 1049Pyridine용매

실험 절차

The title compound (2.6 g, 7.73 mmol) was prepared in three steps from 2-chloropyridine-3-sulfonyl chloride (8.24 g, 38.9 mmol) and 2,6-dimethoxypyridin-4-amine (6.0 g, 38.9 mmol) in pyridine (25 mL) at rt; followed by ammonia in an autoclave at 100° C. for 16 h; followed by 1,1′-carbonyldiimidazole (6.2 g, 38.2 mmol) in 1,2-dichloroethane (100 mL) at 90° C. for 16 h using the methods of (IntF1), steps 1 and 2, and (IntA14), step 3.

출처 및 근거

ORD 기록
ord-2dcd85fadca244248e3d51d403f277d4
출처 데이터셋
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09249160B2

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