Dimethylformamide → 2-(5,6-Dimethoxypyridin-3-yl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772953

반응식

[C:1]([O-:4])([O-])=O.[K+].[K+].FC1C=C(F)C=C(F)C=1CBr.[CH3:18][O:19][C:20]1C(C)=[CH:24][C:23]([N:27]2[C:32](=[O:33])[N:31]([CH2:34][C:35]3[C:40]([F:41])=[CH:39][C:38]([F:42])=[CH:37][C:36]=3[F:43])[C:30]3[CH:44]=[CH:45][CH:46]=[CH:47][C:29]=3[S:28]2(=[O:49])=[O:48])=[CH:22][C:21]=1C.C[N:52](C=O)C>>[CH3:1][O:4][C:21]1[CH:22]=[C:23]([N:27]2[C:32](=[O:33])[N:31]([CH2:34][C:35]3[C:40]([F:41])=[CH:39][C:38]([F:42])=[CH:37][C:36]=3[F:43])[C:30]3[CH:44]=[CH:45][CH:46]=[CH:47][C:29]=3[S:28]2(=[O:49])=[O:48])[CH:24]=[N:52][C:20]=1[O:19][CH3:18]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 27770592,4,6-Trifluorobenzyl bromide

HCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

생성물 1

HCID 727220882-(5,6-Dimethoxypyridin-3-yl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

실험 절차

The title compound (103 mg, 0.21 mmol) was prepared from (IntA19) (84 mg, 0.25 mmol), K2CO3 (104 mg, 0.75 mmol) and 2,4,6-trifluorobenzyl bromide (68 mg, 0.30 mmol) in DMF (2 mL) using the methods of (115).

출처 및 근거

ORD 기록: ord-e2349e97ea3749559ac42fe2258eaa86
출처 데이터셋: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09249160B2

연결된 노트

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