Boron tribromide → 4-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772956노트

반응식

HRID 1772956 반응식
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:16])(=[O:15])[N:7]([C:17]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24]C)=[C:19]([CH3:26])[CH:18]=2)[C:6]1=[O:27].B(Br)(Br)Br.OC1C(C)=CC(N2C(=O)N(CC3C(F)=CC(F)=CC=3F)C3C=CC=CC=3S2(=O)=O)=CC=1C>>[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:15])(=[O:16])[N:7]([C:17]2[CH:18]=[C:19]([CH3:26])[C:20]([OH:24])=[C:21]([CH3:23])[CH:22]=2)[C:6]1=[O:27]

참가 물질

4

반응물 3

HCID 25134Boron tribromideHCID 727212754-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxideHCID 727218952-(4-Hydroxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

생성물 1

HCID 727219884-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide수율 54.2%

실험 절차

The title compound (0.12 g, 0.26 mmol) was prepared from (81) (0.23 g, 0.48 mmol) and boron tribromide (1.0M solution in DCM, 0.60 mL, 0.60 mmol) using the methods of (114).

출처 및 근거

ORD 기록
ord-dfb982258ce642ada7b089db16857294
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249160B2

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