Sodium Carbonate → Oseltamivir

HRID 1773014

반응식

HRID 1773014 반응식
[CH3:1][CH2:2][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:4][CH3:5].P(=O)([O-])[O-].C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[CH3:5][CH2:4][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:2][CH3:1]

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 178469146HCID 178469146, 화합물

생성물 1

HCID 65028Oseltamivir

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A stirred solution of oseltamivir phosphonate (100 mg) in 50 mL DCM was treated with 50 ml aqueous Na2CO3 (60 mg). The white solution was stirred over a period of 45 minutes at room temperature. The combined aqueous and organic layers were extracted with dichloromethane (100 mL) and the organic phase was dried over Na2SO4. The combined organic phases were evaporated in a rotary evaporator to yield the product oseltamivir as a liquid, which was used without further purification in the next step. Oseltamivir amine was

후처리

  1. extractionThe combined aqueous and organic layers were extracted with dichloromethane (100 mL)
  2. dry with materialthe organic phase was dried over Na2SO4
  3. customThe combined organic phases were evaporated in a rotary evaporator

출처 및 근거

ORD 기록
ord-6b928a25700d47eca71c698550f86623
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09250238B2

연결된 노트

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