Thionyl Chloride → 4-Cyano-3-fluorobenzoyl chloride

HRID 1773362노트

반응식

HRID 1773362 반응식
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].O=S(Cl)[Cl:15]>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:15])=[O:8])=[CH:5][C:4]=1[F:12])#[N:2]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 27784684-Cyano-3-fluorobenzoic acid

생성물 1

HCID 199567394-Cyano-3-fluorobenzoyl chloride수율 99%

실험 절차

A mixture of 4-cyano-3-fluoro-benzoic acid (2.0 g, 12.12 mmol) in SOCl2 (20 mL) was refluxed for 2 h, and SOCl2 was removed in vacuo to give 4-cyano-3-fluoro-benzoyl chloride (2.2 g, 99%). The crude was carried to the next step without further purification.

후처리

  1. temperaturewas refluxed for 2 h
  2. customSOCl2 was removed in vacuo

출처 및 근거

ORD 기록
ord-71b94d3b50a94d98bc4ea4d07b409500
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255097B2

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