Potassium Carbonate → Acetamide, N-(3-hydroxy-4-nitrophenyl)-
반응식
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([N+:15]([O-:17])=[O:16])=[C:9]([O:11]C(=O)C)[CH:10]=1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[OH:11][C:9]1[CH:10]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=[CH:7][C:8]=1[N+:15]([O-:17])=[O:16]참가 물질
4
실험 절차
A mixture of acetic acid 5-acetylamino-2-nitro-phenyl ester (20.5 g, 85.77 mmol) and potassium carbonate (26 g, 188.4 mmol) in methanol (200 mL) was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure, water (250 mL) was added and the resulting mixture was acidified by addition of concentrated hydrochloric acid. The solid which crushed out was triturated, collected by filtration, washed with water and dried under vacuum to afford N-(3-hydroxy-4-nitro-phenyl)-acetamide.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure, water (250 mL)
- additionwas added
- additionthe resulting mixture was acidified by addition of concentrated hydrochloric acid
- customThe solid which crushed out
- customwas triturated
- filtrationcollected by filtration
- washwashed with water
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-d5291b0c53284b099630f211e21abe93
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09255110B2
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