Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 2-fluoro-3-nitrobenzoate | HCID 13470961 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester | HCID 59635415 | — |
반응 단계
Methyl 2-fluoro-3-nitrobenzoate (25 g, 0.126 mol) was dissolved in DCM (400 ml) and to this was added Potassium carbonate (34.7 g, 0.25 mol) followed by Methylamine (20.63 ml, 0.5 mol). Reaction was stirred at room temperature under argon. Upon completion reaction was diluted with water and extracted with DCM (3×) then dried over magnesium sulfate. Solvents were removed under reduced pressure to afford methyl 2-(methylamino)-3-nitrobenzoate as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09255089B2 |
| 출처 데이터셋 | uspto-grants-2016_02 |
| ORD ID | ord-7b54cf94915f4dfb8c875f28ccffe5d3 |
| 출처 메모 | uspto-grants-2016_02 |