HCID 117601197, 화합물 → HCID 117601899, 화합물

HRID 1773744노트

반응식

HRID 1773744 반응식
[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]([C:17]([O:19]C)=O)[C:10]3[NH:14][C:13](=[O:15])[NH:12][C:11]=3[CH:16]=2)=[C:5]([CH3:21])[O:4][N:3]=1.[CH:22]1([Mg]Cl)[CH2:26][CH2:25][CH2:24][CH2:23]1>C1COCC1>[CH:22]1([C:17]([C:9]2[C:10]3[NH:14][C:13](=[O:15])[NH:12][C:11]=3[CH:16]=[C:7]([C:6]3[C:2]([CH3:1])=[N:3][O:4][C:5]=3[CH3:21])[CH:8]=2)=[O:19])[CH2:26][CH2:25][CH2:24][CH2:23]1

참가 물질

4

반응물 2

HCID 117601197HCID 117601197, 화합물HCID 178478989HCID 178478989, 화합물

생성물 1

HCID 117601899HCID 117601899, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture containing methyl 6-(3,5-dimethylisoxazol-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate (60 mg, 0.21 mmol, 1 equiv.) and THF (3 mL) is added cyclopentyl magnesium chloride (0.88 mL, 1.46 mmol, 7 equiv.) at 0° C. for 5 min. After completion, the reaction was quenched and extracted with EtOAc and washed with water, saturated NH4Cl. After drying with MgSO4, it was filtered and concentrated to dryness. Purification was carried out by reverse phase HPLC.

후처리

  1. customAfter completion, the reaction was quenched
  2. extractionextracted with EtOAc
  3. washwashed with water, saturated NH4Cl
  4. dry with materialAfter drying with MgSO4, it
  5. filtrationwas filtered
  6. concentrationconcentrated to dryness
  7. customPurification

출처 및 근거

ORD 기록
ord-154bd48e69d64f63bb8e9af71b0db646
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255089B2

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